Document Detail


Discriminative-stimulus effects of triazolam in light and moderate drinkers.
MedLine Citation:
PMID:  12711926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The results of previous laboratory experiments with humans suggest that light and moderate drinkers respond differentially to the effects of benzodiazepines. The aim of this study was to further assess the behavioral effects of a benzodiazepine in light and moderate drinkers. METHODS: To accomplish this aim, 12 volunteers (6 light drinkers and 6 moderate drinkers) learned to discriminate 0.375 mg of triazolam, a triazolobenzodiazepine hypnotic. After they learned this discrimination, a test-of-novel-doses phase was conducted in which a range of doses of triazolam (0, 0.06, 0.125, 0.25, and 0.375 mg) was tested in both groups of volunteers. The subject-rated and performance-impairing effects of triazolam were assessed concurrently. RESULTS: There was not a significant difference between the groups in terms of the number of trials needed to learn the discrimination, nor did the proportion of light and moderate drinkers who learned to accurately discriminate 0.375 mg of triazolam differ significantly. The discriminative-stimulus, subject-rated, and performance-impairing effects of triazolam were an orderly function of dose but did not differ across the light and moderate drinkers. CONCLUSIONS: Future studies should examine the discriminative-stimulus effects of a lower dose of triazolam (e.g., 0.25 mg) in light and moderate drinks or use a fading procedure to determine differences in terms of the lowest discriminable dose.
Authors:
Craig R Rush; Thomas H Kelly; Mark T Fillmore; Lon R Hays
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  27     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-46     Citation Subset:  IM    
Affiliation:
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, USA. crush2@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / psychology*
Analysis of Variance
Discrimination Learning / drug effects*,  physiology
Dose-Response Relationship, Drug
Female
Humans
Male
Psychomotor Performance / drug effects,  physiology
Questionnaires
Triazolam / pharmacology*
Grant Support
ID/Acronym/Agency:
DA 09841/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
28911-01-5/Triazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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