| Discriminative power of different nonmotor signs in early Parkinson's disease. A case-control study. | |
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MedLine Citation:
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PMID: 20198714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the discriminative power of different nonmotor signs for early diagnosis of Parkinson's disease (PD). Thirty patients with PD with <or=3 years of disease duration were compared with 30 healthy controls. Six deficit domains (DD) were defined: hyposmia, sleep abnormalities, dysautonomia, visual deficits, executive dysfunction, and depression. Plotting of Receiver operating characteristic (ROC) curves and exact conditional logistic modeling, followed by manual stepwise descending procedure were used to identify a model for nonmotor signs that detects early PD. Patients with PD and controls did not differ in terms of age, gender, and educational level. Several DD discriminated patients with PD from healthy controls. Visual deficits showed the largest area under the ROC curve (0.83), followed by hyposmia (0.81) and dysautonomia (0.80). When combining the DD visual deficits and dysautonomia, the best residual model was obtained; it maximized both sensitivity and specificity for PD at a level of 0.77. At an early disease stage, several nonmotor domains were already able to discriminate patients with PD from healthy controls. Visual deficits had the best discriminatory power. Being brief and inexpensive, visual tests should be further investigated in larger cohorts as potential screening tool for early PD. |
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Authors:
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Nico J Diederich; Vannina Pieri; Géraldine Hipp; Olivier Rufra; Sara Blyth; Michel Vaillant |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 25 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 882-7 Citation Subset: IM |
Copyright Information:
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(c) 2010 Movement Disorder Society. |
Affiliation:
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Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg. diederdn@pt.lu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Cognition Disorders / diagnosis, epidemiology, physiopathology Depressive Disorder, Major / diagnosis, epidemiology, psychology Diagnosis, Differential Female Frontal Lobe / physiopathology Humans Male Neuropsychological Tests Olfaction Disorders / diagnosis*, epidemiology Parkinson Disease / diagnosis*, epidemiology, physiopathology* Polysomnography REM Sleep Behavior Disorder / diagnosis*, epidemiology Severity of Illness Index Trail Making Test Vision Disorders / diagnosis*, epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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