Document Detail

Discriminative power of different nonmotor signs in early Parkinson's disease. A case-control study.
MedLine Citation:
PMID:  20198714     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the discriminative power of different nonmotor signs for early diagnosis of Parkinson's disease (PD). Thirty patients with PD with <or=3 years of disease duration were compared with 30 healthy controls. Six deficit domains (DD) were defined: hyposmia, sleep abnormalities, dysautonomia, visual deficits, executive dysfunction, and depression. Plotting of Receiver operating characteristic (ROC) curves and exact conditional logistic modeling, followed by manual stepwise descending procedure were used to identify a model for nonmotor signs that detects early PD. Patients with PD and controls did not differ in terms of age, gender, and educational level. Several DD discriminated patients with PD from healthy controls. Visual deficits showed the largest area under the ROC curve (0.83), followed by hyposmia (0.81) and dysautonomia (0.80). When combining the DD visual deficits and dysautonomia, the best residual model was obtained; it maximized both sensitivity and specificity for PD at a level of 0.77. At an early disease stage, several nonmotor domains were already able to discriminate patients with PD from healthy controls. Visual deficits had the best discriminatory power. Being brief and inexpensive, visual tests should be further investigated in larger cohorts as potential screening tool for early PD.
Nico J Diederich; Vannina Pieri; Géraldine Hipp; Olivier Rufra; Sara Blyth; Michel Vaillant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  25     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  882-7     Citation Subset:  IM    
Copyright Information:
(c) 2010 Movement Disorder Society.
Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg.
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MeSH Terms
Case-Control Studies
Cognition Disorders / diagnosis,  epidemiology,  physiopathology
Depressive Disorder, Major / diagnosis,  epidemiology,  psychology
Diagnosis, Differential
Frontal Lobe / physiopathology
Neuropsychological Tests
Olfaction Disorders / diagnosis*,  epidemiology
Parkinson Disease / diagnosis*,  epidemiology,  physiopathology*
REM Sleep Behavior Disorder / diagnosis*,  epidemiology
Severity of Illness Index
Trail Making Test
Vision Disorders / diagnosis*,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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