| Discrimination learning in Rora(sg) and Grid2(ho) mutant mice. | |
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MedLine Citation:
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PMID: 18583162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies. |
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Authors:
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R Lalonde; C Strazielle |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-25 |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 90 ISSN: 1095-9564 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-11-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: United States |
Other Details:
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Languages: eng Pagination: 472-4 Citation Subset: IM |
Affiliation:
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Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, 1058 St-Denis St., Montréal, Que. H2X3J4, Canada. robert.lalonde@umontreal.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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genetics* Alleles Animals Atrophy Avoidance Learning / physiology Cerebellar Cortex / pathology Discrimination Learning / physiology* Escape Reaction / physiology* Fear / physiology Maze Learning / physiology* Mental Recall / physiology Mice Mice, Inbred C57BL Mice, Neurologic Mutants Motivation Neurons / pathology Nuclear Receptor Subfamily 1, Group F, Member 1 Orientation / physiology* Purkinje Cells / pathology Receptors, Cytoplasmic and Nuclear / genetics* Reversal Learning / physiology Spinocerebellar Degenerations / genetics*, pathology* Trans-Activators / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Mona protein, mouse; 0/Nuclear Receptor Subfamily 1, Group F, Member 1; 0/Receptors, Cytoplasmic and Nuclear; 0/Rora protein, mouse; 0/Trans-Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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