Document Detail

Discrimination learning in Rora(sg) and Grid2(ho) mutant mice.
MedLine Citation:
PMID:  18583162     Owner:  NLM     Status:  MEDLINE    
Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies.
R Lalonde; C Strazielle
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-25
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  90     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-11-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-4     Citation Subset:  IM    
Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, 1058 St-Denis St., Montréal, Que. H2X3J4, Canada.
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MeSH Terms
Adaptor Proteins, Signal Transducing / genetics*
Avoidance Learning / physiology
Cerebellar Cortex / pathology
Discrimination Learning / physiology*
Escape Reaction / physiology*
Fear / physiology
Maze Learning / physiology*
Mental Recall / physiology
Mice, Inbred C57BL
Mice, Neurologic Mutants
Neurons / pathology
Nuclear Receptor Subfamily 1, Group F, Member 1
Orientation / physiology*
Purkinje Cells / pathology
Receptors, Cytoplasmic and Nuclear / genetics*
Reversal Learning / physiology
Spinocerebellar Degenerations / genetics*,  pathology*
Trans-Activators / genetics*
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Mona protein, mouse; 0/Nuclear Receptor Subfamily 1, Group F, Member 1; 0/Receptors, Cytoplasmic and Nuclear; 0/Rora protein, mouse; 0/Trans-Activators

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