| Discrimination between Metastasis and Glioblastoma Multiforme Based on Morphometric Analysis of MR Images. | |
| | |
MedLine Citation:
|
PMID: 21051512 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Solitary MET and GBM are difficult to distinguish by using MR imaging. Differentiation is useful before any metastatic work-up or biopsy. Our hypothesis was that MET and GBM tumors differ in morphology. Shape analysis was proposed as an indicator for discriminating these 2 types of brain pathologies. The purpose of this study was to evaluate the accuracy of this approach in the discrimination of GBMs and brain METs. MATERIALS AND METHODS: The dataset consisted of 33 brain MR imaging sets of untreated patients, of which 18 patients were diagnosed as having a GBM and 15 patients, as having solitary metastatic brain tumor. The MR imaging was segmented by using the K-means algorithm. The resulting set of classes (also called "clusters") represented the variety of tissues observed. A morphology-based approach allowed discrimination of the 2 types of tumors. This approach was validated by a leave-1-patient-out procedure. RESULTS: A method was developed for the discrimination of GBMs and solitary METs. Two masses out of 33 were wrongly classified; the overall results were accurate in 93.9% of the observed cases. CONCLUSIONS: A semiautomated method based on a morphologic analysis was developed. Its application was found to be useful in the discrimination of GBM from solitary MET. |
| | |
Authors:
|
L Blanchet; P W T Krooshof; G J Postma; A J Idema; B Goraj; A Heerschap; L M C Buydens |
Publication Detail:
|
Type: Journal Article Date: 2010-11-04 |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 32 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 67-73 Citation Subset: IM |
Affiliation:
|
Institute for Molecules and Materials, Analytical Chemistry Radboud University Nijmegen, Nijmegen, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MR Imaging of Brain Volumes: Evaluation of a Fully Automatic Software.
Next Document: Blood Flow Changes Caused by Distal Filter Protection and Catheter Aspiration in the Internal Caroti...