Document Detail


Discrimination between COPD with and without alpha 1-antitrypsin deficiency using an electronic nose.
MedLine Citation:
PMID:  21883674     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: This study demonstrates that an electronic nose can distinguish the exhaled breath of patients with chronic obstructive pulmonary disease with and without alpha 1-antitrypsin (AAT) deficiency. Furthermore, it can detect an acute effect of human recombinant AAT on exhaled breath. ABSTRACT: BACKGROUND AND OBJECTIVE:  To compare the volatile organic compound pattern of patients with chronic obstructive pulmonary disease (COPD) with and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology. METHODS:  Exhaled breath condensate and pure exhaled breath of patients with COPD with (n= 10) and without (n= 23) AAT deficiency and healthy controls (n= 10) were analysed. The effect of human recombinant AAT on the volatile organic compound profile of 11 AAT-deficient patients was also examined. Exhaled breath condensate and pure exhaled breath were measured using the Cyranose 320™. Smell-prints were analysed by linear discriminant analysis (LDA) using Mahalanobis distance (MD) and cross-validation values (CVV). RESULTS:  Smell-prints from patients with AAT-deficiency were different from those with COPD in exhaled breath condensate (LDA: p < 0.0001, sensitivity of 1.00, specificity of 1.00, CVV 82.0 %, MD 2.37), and in pure exhaled breath (LDA: p < 0.0001, sensitivity of 1.00, specificity of 1.00, CVV 58.3 %, MD 2.27). Smell-prints of AAT-deficient patients before and after human recombinant AAT were different (LDA: p= 0.001, sensitivity of 1.00, specificity of 1.00, CVV 53.3 %, MD 1.79). CONCLUSIONS:  An electronic nose can detect differences in smell-prints in COPD patients with or without AAT deficiency. Augmentation therapy changes the volatile organic compound pattern. The electronic nose may be helpful in the diagnosis of AAT deficiency.
Authors:
Akira D M Hattesohl; Rudolf A Jörres; Holger Dressel; Severin Schmid; Claus Vogelmeier; Timm Greulich; Sarah Noeske; Robert Bals; Andreas Rembert Koczulla
Related Documents :
20039124 - The association of glomerular filtration rate and erectile dysfunction with severity of...
17550784 - Low serum adiponectin is independently associated with both the metabolic syndrome and ...
18035074 - Association of polymorphisms in platelet and hemostasis system genes with acute myocard...
9127224 - Atherosclerotic risk factors are less intensively treated in patients with peripheral a...
22794694 - Chapter 21: urticaria and angioedema.
1711614 - Potassium supplementation versus bendrofluazide in mildly to moderately hypertensive ke...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology.
Affiliation:
Department for Internal Medicine, Division for Pulmonary Diseases, Philipps-Universität Marburg, 35043 Marburg, Germany Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität Munich, 80336 Munich, Germany Department of Internal Medicine V, Pulmonology, Allergology, Respiratory and Environmental Medicine, Saarland University Hospital, 66421 Homburg/Saar, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blind Peritoneal Catheter Placement with a Tenckhoff Trocar by Nephrologists: A Single-Center Experi...
Next Document:  Weakness of expiratory muscles and pulmonary complications in malnourished patients undergoing upper...