| Discrimination between COPD with and without alpha 1-antitrypsin deficiency using an electronic nose. | |
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MedLine Citation:
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PMID: 21883674 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARY AT A GLANCE: This study demonstrates that an electronic nose can distinguish the exhaled breath of patients with chronic obstructive pulmonary disease with and without alpha 1-antitrypsin (AAT) deficiency. Furthermore, it can detect an acute effect of human recombinant AAT on exhaled breath. ABSTRACT: BACKGROUND AND OBJECTIVE: To compare the volatile organic compound pattern of patients with chronic obstructive pulmonary disease (COPD) with and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology. METHODS: Exhaled breath condensate and pure exhaled breath of patients with COPD with (n= 10) and without (n= 23) AAT deficiency and healthy controls (n= 10) were analysed. The effect of human recombinant AAT on the volatile organic compound profile of 11 AAT-deficient patients was also examined. Exhaled breath condensate and pure exhaled breath were measured using the Cyranose 320™. Smell-prints were analysed by linear discriminant analysis (LDA) using Mahalanobis distance (MD) and cross-validation values (CVV). RESULTS: Smell-prints from patients with AAT-deficiency were different from those with COPD in exhaled breath condensate (LDA: p < 0.0001, sensitivity of 1.00, specificity of 1.00, CVV 82.0 %, MD 2.37), and in pure exhaled breath (LDA: p < 0.0001, sensitivity of 1.00, specificity of 1.00, CVV 58.3 %, MD 2.27). Smell-prints of AAT-deficient patients before and after human recombinant AAT were different (LDA: p= 0.001, sensitivity of 1.00, specificity of 1.00, CVV 53.3 %, MD 1.79). CONCLUSIONS: An electronic nose can detect differences in smell-prints in COPD patients with or without AAT deficiency. Augmentation therapy changes the volatile organic compound pattern. The electronic nose may be helpful in the diagnosis of AAT deficiency. |
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Authors:
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Akira D M Hattesohl; Rudolf A Jörres; Holger Dressel; Severin Schmid; Claus Vogelmeier; Timm Greulich; Sarah Noeske; Robert Bals; Andreas Rembert Koczulla |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-24 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology. |
Affiliation:
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Department for Internal Medicine, Division for Pulmonary Diseases, Philipps-Universität Marburg, 35043 Marburg, Germany Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität Munich, 80336 Munich, Germany Department of Internal Medicine V, Pulmonology, Allergology, Respiratory and Environmental Medicine, Saarland University Hospital, 66421 Homburg/Saar, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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