| Discrimination between T/A and A/T Base Pairs of Pyrrole-Imidazole Polyamides Substituted with Chiral β-Hydroxy-γ-Aminobutyric Acid/β-Alanine Pairs. | |
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MedLine Citation:
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PMID: 22113893 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Base-T-specific recognition element: A chiral aliphatic amino acid, (S)-β-hydroxyl-γ-aminobutyric acid, when incorporated into polyamides, can act as a novel T-specific recognition element in DNA minor groove sequence-specific recognition event. Good flexibility of the novel T-reader implies that it could be incorporated into longer polyamides to regulate their curvature and thus allow discrimination of longer DNA sequences. |
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Authors:
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Wen Zhang; Shi-Kun Jiang; Yan-Ling Wu; Chuan-Xin Guo; Hong-Fei Zhang; Hiroshi Sugiyama; Xing-Lai Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: - ISSN: 1439-7633 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014 (China). wzhang63@zjut.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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