| Discrimination between Sjögren's and non-Sjögren's sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens. | |
| | |
MedLine Citation:
|
PMID: 19761691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens alpha-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were alpha-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum alpha-fodrin, Ro and La might be useful for SS and NSS discrimination. |
| | |
Authors:
|
K-S Chen; M-C Jiang; C-J Li; O-K Liu; C-S S Tsai |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of international medical research Volume: 37 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2009 Jul-Aug |
Date Detail:
|
Created Date: 2009-09-18 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
|
Languages: eng Pagination: 1088-96 Citation Subset: IM |
Affiliation:
|
Department of Allergy, Immunology and Rheumatology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autoantibodies
/
immunology* Autoantigens / analysis, blood, immunology Biological Markers / blood Carrier Proteins / immunology Diagnosis, Differential Female Humans Male Microfilament Proteins / immunology Middle Aged Radionuclide Imaging / methods* Ribonucleoproteins / analysis, immunology Salivary Glands / pathology*, radionuclide imaging Sjogren's Syndrome / diagnosis*, immunology Xerophthalmia / diagnosis*, immunology |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Autoantigens; 0/Biological Markers; 0/Carrier Proteins; 0/Microfilament Proteins; 0/Ribonucleoproteins; 0/SS-A antigen; 0/SS-B antigen; 0/fodrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transplanted Bone Morphogenetic Protein/Poly(lactic-co-glycolic Acid) Delayed-release Microcysts Com...
Next Document: Insulin with Chondroitinase ABC Treats the Rat Model of Acute Spinal Cord Injury.