Document Detail

Discriminating patients with frontal-lobe epilepsy and temporal-lobe epilepsy: utility of a multilevel design fluency test.
MedLine Citation:
PMID:  16351356     Owner:  NLM     Status:  MEDLINE    
Patients with frontal-lobe epilepsy (FLE) or temporal-lobe epilepsy (TLE) and matched control participants were given a design fluency test that assessed nonverbal fluency and switching ability. Patients with FLE generated fewer designs in the switching condition relative to the TLE patients and controls, whereas group differences did not emerge in the basic fluency conditions. When the side of the seizure focus and the presence or absence of a structural lesion were considered in patients with FLE, only those with left-lesional FLE generated fewer designs than controls did in the switching condition. Furthermore, patients with left-lesional and nonlesional FLE produced a greater proportion of set-loss errors than did controls. These results indicate that patients with FLE are impaired when they must simultaneously generate new designs and engage in cognitive switching; however, the pattern of impairment may depend on the side of the seizure focus and the presence of a structural lesion.
Carrie R McDonald; Dean C Delis; Marc A Norman; Evelyn S Tecoma; Vicente J Iragui
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychology     Volume:  19     ISSN:  0894-4105     ISO Abbreviation:  Neuropsychology     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904467     Medline TA:  Neuropsychology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  806-13     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 APA, all rights reserved.
Veterans Administration San Diego Healthcare System, La Jolla, CA 92611, and Department of Psychiatry, University of California, San Diego, CA, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Epilepsy, Frontal Lobe / diagnosis*,  physiopathology
Epilepsy, Temporal Lobe / diagnosis*,  physiopathology
Functional Laterality / physiology
Middle Aged
Neuropsychological Tests / statistics & numerical data*
Problem Solving / physiology
Grant Support

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