Document Detail

Discriminant function using red cell indices to distinguish between HbC and HbE traits.
MedLine Citation:
PMID:  7621626     Owner:  NLM     Status:  MEDLINE    
Values for MCV, MCH, MCHC and red cell distribution width (RDW) derived from subjects with HbC and HbE traits using a Technicon H*1 automated blood count analyser were compared. Significantly higher MCH, MCHC and RDW values were found in those with HbC trait. By use of a simple discriminant function (MCHC2 x RDW/1000), 19/20 subjects with HbC trait gave a value > or = 16.3, and 20/21 subjects with HbE trait gave a value < or = 16.2. The function described may be of value as an adjunct to electrophoresis in intralaboratory quality control.
R F Hinchliffe; S P Ellis; J S Lilleyman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  17     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM    
Section of Paediatric Haematology, University of Sheffield Department of Paediatrics, Children's Hospital, Western Bank, UK.
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MeSH Terms
Blood Cell Count
Child, Preschool
Diagnosis, Differential
Discriminant Analysis
Erythrocyte Indices*
Hemoglobin C / analysis*,  genetics
Hemoglobin E / analysis*,  genetics
Hemoglobinuria / blood,  diagnosis*,  genetics
Reg. No./Substance:
9008-00-8/Hemoglobin C; 9034-61-1/Hemoglobin E
Comment In:
Clin Lab Haematol. 1996 Jun;18(2):128-9   [PMID:  8866152 ]

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