| Discriminant analysis of thallium-201 myocardial scintigrams. | |
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MedLine Citation:
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PMID: 4000565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a group of 207 patients undergoing coronary angiography, myocardial scintigrams have been performed at rest (n = 95), after exercise testing (n = 50) or after dipyridamole vasodilation (n = 62). Pictures recorded in anterior and 45 degrees left anterior oblique projections have been analysed according to a model which divides each projection into 5 territories. Thallium uptake has been visually assessed using a three grade scale: 0 = normal uptake, + = sightly abnormal uptake, ++ = evident hypoactivity. With reference to angiography, sensitivity and specificity for prediction of coronary artery disease have been calculated in a classical way using three different criteria of positivity of increasing severity, and by a computerized method based on discriminant analysis. In the first case, sensitivity and specificity were highly dependent one on the other and, as could be expected, varied in opposite directions, a high sensitivity (89 to 100%) being only achieved by accepting a lack of specificity (33 to 57%). Discriminant analysis, on the contrary, provided for each type of protocol: rest, stress, dipyridamole and redistribution, a single optimized combination of sensitivity (74 to 87%) and specificity (92 to 100%). The corresponding point, when located on the receiver operating characteristics (ROC) diagram, demonstrated a clear improvement in diagnostic accuracy. The same method has been applied for discrimination, not only between normals and abnormals, but also between normals and patients with and without myocardial infarction (correct diagnosis in 50 to 68% of cases), and between normals and patients with single-, double- or triple-vessel disease (correct diagnosis in 17 to 65% of cases) with a high specificity (correct classification of normals in 86 to 100% of cases). |
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Authors:
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L Benjelloun; H Benjelloun; M Laudet; R Itti |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 6 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-07-25 Completed Date: 1985-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 149-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Angiography Coronary Disease / radiography, radionuclide imaging Coronary Vessels / drug effects Decision Theory Dipyridamole / pharmacology Exercise Test Heart / radionuclide imaging* Humans Radioisotopes / diagnostic use* Thallium / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 58-32-2/Dipyridamole; 7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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