Document Detail


Discriminant analysis of brain imaging data identifies subjects with early Alzheimer's disease.
MedLine Citation:
PMID:  9447444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vivo functional brain imaging provides an opportunity to quantify and localize functional deficits associated with Alzheimer's disease (AD), in relation to dementia severity and heterogeneous cognitive profiles. Such imaging also provides a basis for distinguishing AD from other causes of dementia and for making an early diagnosis of disease. One imaging modality that can elucidate AD is positron emission tomography (PET), which is used to measure regional cerebral metabolic rates for glucose (rCMRglc) and regional cerebral blood flow (rCBF). Resting-state measurements with PET, when related to cognitive profiles in longitudinal studies, indicate that specific cognitive defects are preceded and predicted by reductions in rCMRglc in regions subserving the cognitive functions tested. Metabolic reductions and right/left metabolic asymmetries can be used to convert a "possible" to a "probable" diagnosis of AD by the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria. Furthermore, discriminant analyses of PET metabolic patterns can identify patients at risk for AD with mild memory deficits as having probable AD. In the future, stimulation PET studies should augment the power of this discriminant analysis.
Authors:
S I Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  9 Suppl 1     ISSN:  1041-6102     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-15     Completed Date:  1998-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-35; discussion 247-52     Citation Subset:  IM    
Affiliation:
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Alzheimer Disease / complications,  genetics,  radionuclide imaging*
Apolipoproteins E / genetics,  metabolism
Brain / blood supply,  metabolism,  radionuclide imaging*
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 14
Cognition Disorders / etiology
Functional Laterality
Glucose / metabolism
Humans
Linkage (Genetics) / genetics
Regional Blood Flow
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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