Document Detail


Discrete time hazards models for occupational and environmental cohort analyses.
MedLine Citation:
PMID:  20029026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To discuss the use of discrete time hazards models for the analysis of occupational and environmental cohort data. METHODS: Analytical data structures and regression methods for discrete time hazards models are described. This approach is illustrated via analyses of data from a study of mortality in a cohort of chemical workers exposed to dioxin. Results and CONCLUSIONS: Analyses employing a discrete time hazards model facilitate examination of observed and expected counts, the calculation of attributable fractions, and empirical description of the estimated hazard rates. In addition, this approach can be used to fit non-multiplicative models, such as the linear hazards ratio model (which has been employed in epidemiological analyses of a variety of environmental and occupational exposures).
Authors:
D B Richardson
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  67     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-23     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. david.richardson@unc.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Chemical Industry
Cohort Studies
Environmental Exposure / statistics & numerical data*
Environmental Pollutants / adverse effects
Humans
Male
Neoplasms / mortality
Occupational Exposure / statistics & numerical data
Proportional Hazards Models
Statistics as Topic / methods*
Tetrachlorodibenzodioxin / adverse effects
Grant Support
ID/Acronym/Agency:
R01-CA117841/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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