| Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. | |
| | |
MedLine Citation:
|
PMID: 8458334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The concentration of cyclin B transcripts at the posterior pole of the Drosophila oocyte occurs at a late stage of oogenesis and is dependent on the sequence in the 3' untranslated part of the RNA. These transcripts become incorporated into the pole cells of the developing embryo and persist through a subsequent period of embryogenesis in which these cells are not dividing. We show that RNA injected into the posterior cytoplasm of syncytial embryos accumulates in the pole cells if it contains sequences present in the 3' untranslated region of maternal cyclin B transcripts. The injected RNA is not translated until a point prior to the resumption of mitosis by these cells, once they have become incorporated into the gonads. Zygotic transcription directed from the cyclin B promoter does not begin in the pole cells until the first instar larva has hatched. Deletion of a small sequence element from the 3' untranslated region of an epitope tagged cyclin B RNA does not affect its posterior accumulation but results in its premature translation. |
| | |
Authors:
|
B Dalby; D M Glover |
Related Documents
:
|
17018634 - The differential staurosporine-mediated g1 arrest in normal versus tumor cells is depen... 12068124 - Variation in growth rate between arabidopsis ecotypes is correlated with cell division ... 11463844 - Reconstitution of cyclin d1-associated kinase activity drives terminally differentiated... 11895924 - Resveratrol induces growth inhibition, s-phase arrest, apoptosis, and changes in biomar... 3568134 - Cell junctions during the early development of the sea urchin embryo (paracentrotus liv... 21190674 - In vivo nmr metabolic profiling of fabrea salina reveals sequential defense mechanisms ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The EMBO journal Volume: 12 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 1993 Mar |
Date Detail:
|
Created Date: 1993-04-23 Completed Date: 1993-04-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 8208664 Medline TA: EMBO J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1219-27 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Physiology, The University, Dundee, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Base Sequence Chimera Cyclins / genetics* DNA Drosophila Female Gonads / embryology, metabolism Larva Male Molecular Sequence Data Protein Biosynthesis* RNA, Messenger / genetics* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/Cyclins; 0/RNA, Messenger; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence for an interaction between the CYP1(HAP1) activator and a cellular factor during heme-depen...
Next Document: The low abundance of U7 snRNA is partly determined by its Sm binding site.