Document Detail

Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila.
MedLine Citation:
PMID:  8458334     Owner:  NLM     Status:  MEDLINE    
The concentration of cyclin B transcripts at the posterior pole of the Drosophila oocyte occurs at a late stage of oogenesis and is dependent on the sequence in the 3' untranslated part of the RNA. These transcripts become incorporated into the pole cells of the developing embryo and persist through a subsequent period of embryogenesis in which these cells are not dividing. We show that RNA injected into the posterior cytoplasm of syncytial embryos accumulates in the pole cells if it contains sequences present in the 3' untranslated region of maternal cyclin B transcripts. The injected RNA is not translated until a point prior to the resumption of mitosis by these cells, once they have become incorporated into the gonads. Zygotic transcription directed from the cyclin B promoter does not begin in the pole cells until the first instar larva has hatched. Deletion of a small sequence element from the 3' untranslated region of an epitope tagged cyclin B RNA does not affect its posterior accumulation but results in its premature translation.
B Dalby; D M Glover
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  12     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-23     Completed Date:  1993-04-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1219-27     Citation Subset:  IM    
Department of Anatomy and Physiology, The University, Dundee, UK.
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MeSH Terms
Base Sequence
Cyclins / genetics*
Gonads / embryology,  metabolism
Molecular Sequence Data
Protein Biosynthesis*
RNA, Messenger / genetics*
Transcription, Genetic
Reg. No./Substance:
0/Cyclins; 0/RNA, Messenger; 9007-49-2/DNA

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