Document Detail


Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in awake portal hypertensive rats.
MedLine Citation:
PMID:  2912829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of increasing doses of propranolol were studied in awake portal hypertensive rats in order to elucidate the relative effects of the beta-blocker on systemic and splanchnic circulation. Hemodynamic responses to 0.1, 0.2 and 0.4 mg per min infusions of propranolol were compared with placebo in awake rats with portal hypertension due to portal vein stenosis. Heart rate significantly and progressively decreased from 356 +/- 13 to 293 +/- 10 beats per min (mean +/- S.E.). Cardiac output significantly decreased from 54 +/- 3 to 42 +/- 3 ml per min per 100 gm body weight at the highest dose. Significant decrease in portal tributary blood flow from 27 +/- 1 to 18 +/- 1 ml per min, at 0.4 mg per min dose, was due not only to the decrease in cardiac output but also to a significant increase in portal tributary vascular resistance from 269 +/- 17 to 368 +/- 31 dyne per sec per cm5 x 10(3). However, portal pressure showed only an insignificant decrease from 14.9 +/- 1.1 to 14.1 +/- 1.4 mmHg. The reduction in portal pressure being minimal, in spite of a significant decrease in portal tributary blood flow, is explained by an increase in combined hepatic and collateral resistance from 44 +/- 2 to 66 +/- 4 dyne per sec per cm5 x 10(3), p less than 0.05, at 0.4 mg per min dose. We conclude that the systemic and splanchnic effects of propranolol show discrepancy at two levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A Koshy; C Girod; S S Lee; A Hadengue; R Cerini; D Lebrec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  9     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-06     Completed Date:  1989-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
Affiliation:
Unité de Recherches de Physiopathologie Hépatique (INSERM U-24), Hôpital Beaujon, Clichy, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / drug effects
Blood Pressure / drug effects*
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension, Portal / physiopathology*
Male
Portal Vein / physiopathology*
Propranolol / administration & dosage,  pharmacology*
Rats
Rats, Inbred Strains
Splanchnic Circulation / drug effects*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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