Document Detail

Discrepancy between effects of in vivo and in vitro administration of gammaglobulin on phagocytic killing of Streptococcus pneumoniae in an antibody-deficient serum.
MedLine Citation:
PMID:  2457557     Owner:  NLM     Status:  MEDLINE    
Phagocytic killing of Streptococcus pneumoniae serotypes 6A, 14, 18C, 19F and 23F was investigated in the dysgammaglobulinemic serum of a patient with recurrent pneumococcal infections. Previous studies with this serum had established combined IgG2, IgG4 and IgA deficiency, deficiency with regard to specific antipolysaccharide antibodies and essentially normal complement functions. Phagocytic killing of all serotypes was reduced in the patient's serum. Addition of immunoglobulin in vitro enhanced both classical and alternative complement pathway mediated opsonization. In constitution experiments neither purified Clq nor CRP influenced phagocytic killing. Surprisingly, intramuscular administration of a fairly small dose of gammaglobulin to the patient was associated with a rapid increase in the serum opsonic activity for serotype 23F. The increased opsonization occurred before specific anticapsular antibodies were detectable in serum. The findings suggest that the possible effects of gammaglobulin treatment may not exclusively be related to the acquisition of serotype-specific antibodies.
J H Braconier; K Prellner; A G Sjöholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  86     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-12     Completed Date:  1988-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  426-31     Citation Subset:  IM    
Department of Infectious Diseases, University Hospital of Lund, Sweden.
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MeSH Terms
Complement Activating Enzymes / pharmacology
Complement C1 / pharmacology
Complement C1q
Complement Pathway, Alternative
Dysgammaglobulinemia / blood
IgG Deficiency
Injections, Intravenous
Opsonin Proteins / metabolism
Phagocytosis* / drug effects
Streptococcus pneumoniae / immunology*
gamma-Globulins / administration & dosage*
Reg. No./Substance:
0/Complement C1; 0/Opsonin Proteins; 0/gamma-Globulins; 80295-33-6/Complement C1q; EC 3.-/Complement Activating Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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