| Discrepancies in cytogenetic findings in chorionic villi. | |
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MedLine Citation:
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PMID: 9438219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a database and a review of published literature on discrepancies in chorionic villus (CV) diagnostic findings. The review includes 457 cases of discrepancies between CV findings (direct, culture, or both) and the fetus. One hundred and one cases reported normal by CV direct harvest included 30 with abnormal or mosaic abnormal fetal karyotype (30% false negatives). The corresponding number of false negatives for CV culture was only 4 cases out of 133 (3%). Assuming no bias in reporting cases based on site of discrepancy (assumption may not hold), these data imply that the probability of false-negative findings is 10-fold higher by CV direct method compared to CV culture method. We also reviewed recent studies reporting on large series of CV diagnosis. This review revealed that the reported overall frequencies of discrepancies as a percentage of abnormal and mosaic abnormal CV results ranged from 11 to 63% (a mean of 37%). These data, together with recent reports of survival of embryos with reported abnormal karyotypes because of confined placental mosaicism (CPM), raise several questions pertaining to the predictive value of CV sampling and the origin of the discrepancies in the fetal-placental unit. Caution is recommended in counseling patients undergoing CV sampling to provide appropriate follow-up studies in cases of possible discrepancies. |
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Authors:
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M B Qumsiyeh; S G Adhvaryu; T Peters-Brown; L Fry-Mehltretter; S M Kath; H H Kay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of maternal-fetal medicine Volume: 6 ISSN: 1057-0802 ISO Abbreviation: J Matern Fetal Med Publication Date: 1997 Nov-Dec |
Date Detail:
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Created Date: 1998-02-09 Completed Date: 1998-02-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9211288 Medline TA: J Matern Fetal Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Affiliation:
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Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. qumsi001@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Villi Sampling* Chromosome Aberrations* Databases, Factual False Negative Reactions False Positive Reactions Female Fetus Humans Karyotyping* Mosaicism* Placenta Pregnancy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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