Document Detail


Discovery of an organic trefoil knot.
MedLine Citation:
PMID:  23139329     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Molecular knots remain difficult to produce using the current synthetic methods of chemistry because of their topological complexity. We report here the near-quantitative self-assembly of a trefoil knot from a naphthalenediimide-based aqueous disulfide dynamic combinatorial library. The formation of the knot appears to be driven by the hydrophobic effect and leads to a structure in which the aromatic components are buried while the hydrophilic carboxylate groups remain exposed to the solvent. Moreover, the building block chirality constrains the topological conformation of the knot and results in its stereoselective synthesis. This work demonstrates that the hydrophobic effect provides a powerful strategy to direct the synthesis of entwined architectures.
Authors:
Nandhini Ponnuswamy; Fabien B L Cougnon; Jessica M Clough; G Dan Pantoş; Jeremy K M Sanders
Related Documents :
21588079 - Tl(2)mo(9)se(11).
22262509 - Reversible heterochiral aggregation/dissociation of bis(2-hydroxyphenyl)diamides driven...
24730649 - A porous metal-organic framework with dynamic pyrimidine groups exhibiting record high ...
19383559 - Elastic layer-structured metal organic frameworks (elms).
20364849 - Three-dimensional porous metal-organic frameworks exhibiting metamagnetic behaviors: sy...
12866939 - Influence of solvents on the variety of crystalline forms of erythromycin.
22199629 - [(1,2,5,6-η)-cyclo-octa-1,5-diene]bis-(1-isopropyl-3-methyl-imidazolin-2-yl-idene)rhod...
22370049 - Thermodynamic estimation of minor element distribution between immiscible liquids in fe...
22582709 - Three-dimensional metal scaffold supported bicontinuous silicon battery anodes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  338     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  783-5     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Cambridge, Cambridge, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment In:
Science. 2012 Nov 9;338(6108):752-3   [PMID:  23139321 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Driving a macroscopic oscillator with the stochastic motion of a hydrogen molecule.
Next Document:  Development and disintegration of Maya political systems in response to climate change.