Document Detail

Discovery of an organic trefoil knot.
MedLine Citation:
PMID:  23139329     Owner:  NLM     Status:  In-Process    
Molecular knots remain difficult to produce using the current synthetic methods of chemistry because of their topological complexity. We report here the near-quantitative self-assembly of a trefoil knot from a naphthalenediimide-based aqueous disulfide dynamic combinatorial library. The formation of the knot appears to be driven by the hydrophobic effect and leads to a structure in which the aromatic components are buried while the hydrophilic carboxylate groups remain exposed to the solvent. Moreover, the building block chirality constrains the topological conformation of the knot and results in its stereoselective synthesis. This work demonstrates that the hydrophobic effect provides a powerful strategy to direct the synthesis of entwined architectures.
Nandhini Ponnuswamy; Fabien B L Cougnon; Jessica M Clough; G Dan Pantoş; Jeremy K M Sanders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  338     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  783-5     Citation Subset:  IM    
Department of Chemistry, University of Cambridge, Cambridge, UK.
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Comment In:
Science. 2012 Nov 9;338(6108):752-3   [PMID:  23139321 ]

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