Document Detail


Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
MedLine Citation:
PMID:  22019296     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new class of MCHR1 antagonists was discovered via a high-throughput screen. Optimization of the lead structure resulted in the identification of indole 10e. This compound possesses good pharmacokinetic properties across preclinical species and is efficacious in reducing food consumption in an MCH cannulated rat model and a cynomolgus monkey food consumption model.
Authors:
Jeffrey T Mihalic; Xiaoqi Chen; Pingchen Fan; Xi Chen; Ying Fu; Lingming Liang; Michael Reed; Liang Tang; Jin-Long Chen; Juan Jaen; Leping Li; Kang Dai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-5
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Department of Medicinal Chemistry, Amgen, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
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