Document Detail


Discovery of novel glitazones incorporated with phenylalanine and tyrosine: Synthesis, antidiabetic activity and structure-activity relationships.
MedLine Citation:
PMID:  23064124     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report a series of new glitazones incorporated with phenylalanine and tyrosine. All the compounds were tested for their in vitro glucose uptake activity using rat-hemidiaphragm, both in presence and absence of insulin. Six of the most active compounds from the in vitro screening were taken forward for their in vivo triglyceride and glucose lowering activity against dexamethazone induced hyperlipidemia and insulin resistance in Wistar rats. The liver samples of rats that received the most active compounds, 23 and 24, in the in vivo studies, were subjected to histopathological examination to assess their short term hepatotoxicity. The investigations on the in vitro glucose uptake, in vivo triglyceride and glucose lowering activity are described here along with the quantitative structure-activity relationships.
Authors:
B R Prashantha Kumar; Nasir R Baig; Sai Sudhir; Koyal Kar; M Kiranmai; M Pankaj; Nanjan M Joghee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Bioorganic chemistry     Volume:  45C     ISSN:  1090-2120     ISO Abbreviation:  Bioorg. Chem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1303703     Medline TA:  Bioorg Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  12-28     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore 570 015, India.
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