Document Detail


Discovery of new inhibitor for PDE3 by virtual screening.
MedLine Citation:
PMID:  21330134     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this work, we tried to find a new scaffold for a PDE3 using virtual screening for the obesity treatment. We first analyzed structural features for the known PDE3 inhibitors based on the PDE3B-ligand complex structure, and then carried out a docking study based on PDE3B 3D structure. We obtained a compound as potent PDE3 inhibitor stimulating lipolysis in murine adipocytes and human adipocytes.
Authors:
Ki Young Kim; Hyuk Lee; Sung-Eun Yoo; Seong Hwan Kim; Nam Sook Kang
Related Documents :
19047004 - Ketosynthase iii as a gateway to engineering the biosynthesis of antitumoral benastatin...
8282114 - Effect of neutral and acidic phospholipids on mitochondrial atp synthase secondary stru...
19859664 - Spermine synthase.
15471444 - Design, synthesis, and evaluation of acyclic c-nucleoside and n-methylated derivatives ...
24946894 - The structure of a pii signaling protein from a halophilic archaea reveals novel traits...
6573204 - Identification of the catalytic subunit of an oligomeric casein kinase (g type). affini...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-2
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Bio-Organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, South Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Knitting and snipping: chaperones in ?-helix folding.
Next Document:  Mind your step: Metabolic energy cost while walking an enforced gait pattern.