Document Detail

Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro.
MedLine Citation:
PMID:  25262542     Owner:  NLM     Status:  Publisher    
Efficient methods for the preparation of 5'-substituted 5'-amino-5'-deoxy-N(6)-ureidoadenosine derivatives are described. Compounds were screened for antiproliferative activity against a panel of murine and human cell lines (L1210, CEM, and HeLa) and/or against the NCI-60. The most potent derivative inhibited the lung adenocarcinoma cell line NCI-H522 at low nanomolar concentrations (GI50=9.7nM).
Jadd R Shelton; Jan Balzarini; Matt A Peterson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-3
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-28     Completed Date:  -     Revised Date:  2014-9-30    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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