Document Detail


Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.
MedLine Citation:
PMID:  22237952     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.
Authors:
Jean-Pierre Daguer; Mihai Ciobanu; Sofia Barluenga; Nicolas Winssinger
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg-CNRS (UMR 7006), 8 allee Gaspard Monge, 67000, Strasbourg, France. winssinger@isis.u-strasbg.fr.
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