| Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring. | |
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MedLine Citation:
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PMID: 21793965 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Scarring in the skin following surgery or trauma may be associated with adverse aesthetic, functional, growth and psychological effects, such that both physicians and patients regard it as important to minimize the appearance of scars. The prophylactic improvement of cutaneous scar appearance represents a significant opportunity to improve the well-being of patients. Human recombinant transforming growth factor beta 3 (avotermin) is the first in a new class of therapeutic agents to address this medical need. Herein we describe scar-free healing in early embryonic development, including the identification of the cellular and molecular mechanisms underpinning the scarring process. This understanding has led to the discovery of novel therapeutics such as transforming growth factor beta 3, which can be administered to improve scar appearance in human subjects through pharmacological action. We discuss the pioneering development of transforming growth factor beta 3 in this new therapeutic area showing how it has been possible to translate preclinical concepts into clinical application, namely the improvement of scar appearance following surgery. |
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Authors:
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Nick L Occleston; Sharon O'Kane; Hugh G Laverty; Mark Cooper; David Fairlamb; Tracey Mason; Jim A Bush; Mark W J Ferguson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Volume: 19 Suppl 1 ISSN: 1524-475X ISO Abbreviation: Wound Repair Regen Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310939 Medline TA: Wound Repair Regen Country: United States |
Other Details:
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Languages: eng Pagination: s38-48 Citation Subset: IM |
Copyright Information:
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© 2011 by the Wound Healing Society. |
Affiliation:
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Renovo, Manchester Core Technology Facility, Manchester, United Kingdom. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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