Document Detail

Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring.
MedLine Citation:
PMID:  21793965     Owner:  NLM     Status:  In-Data-Review    
Scarring in the skin following surgery or trauma may be associated with adverse aesthetic, functional, growth and psychological effects, such that both physicians and patients regard it as important to minimize the appearance of scars. The prophylactic improvement of cutaneous scar appearance represents a significant opportunity to improve the well-being of patients. Human recombinant transforming growth factor beta 3 (avotermin) is the first in a new class of therapeutic agents to address this medical need. Herein we describe scar-free healing in early embryonic development, including the identification of the cellular and molecular mechanisms underpinning the scarring process. This understanding has led to the discovery of novel therapeutics such as transforming growth factor beta 3, which can be administered to improve scar appearance in human subjects through pharmacological action. We discuss the pioneering development of transforming growth factor beta 3 in this new therapeutic area showing how it has been possible to translate preclinical concepts into clinical application, namely the improvement of scar appearance following surgery.
Nick L Occleston; Sharon O'Kane; Hugh G Laverty; Mark Cooper; David Fairlamb; Tracey Mason; Jim A Bush; Mark W J Ferguson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  19 Suppl 1     ISSN:  1524-475X     ISO Abbreviation:  Wound Repair Regen     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  s38-48     Citation Subset:  IM    
Copyright Information:
© 2011 by the Wound Healing Society.
Renovo, Manchester Core Technology Facility, Manchester, United Kingdom.
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