Document Detail

Discovery of a cholecystokinin-releasing peptide: biochemical characterization and physiological implications.
MedLine Citation:
PMID:  10707884     Owner:  NLM     Status:  MEDLINE    
Recent studies indicate that the secretion of CCK is mediated by a trypsin sensitive peptide secreted by the proximal small intestine that has been designated "CCK-releasing factor" (CCK-RF). This CCK-RF was found to be identical to the porcine diazepam binding inhibitor by peptide sequencing and mass spectrometry analysis. This peptide is present in abundance in the epithelial cells in the duodenal mucosa. Its release into the lumen is mediated by intestinal submucosal cholinergic neurons. Functionally, this peptide appears to mediate feedback regulation of pancreatic secretion and CCK release in response to peptone and lipid stimulation. It fulfills all the criteria as a physiological regulator of CCK secretion. This represents the first chemical characterization of a luminally secreted enteric peptide functioning as an intraluminal regulator of intestinal hormone release.
C Owyang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Chinese journal of physiology     Volume:  42     ISSN:  0304-4920     ISO Abbreviation:  Chin J Physiol     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  7804502     Medline TA:  Chin J Physiol     Country:  CHINA (REPUBLIC: 1949- )    
Other Details:
Languages:  eng     Pagination:  113-20     Citation Subset:  IM    
Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor 48109, USA.
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MeSH Terms
Amino Acid Sequence
Duodenum / innervation,  metabolism*
Feedback / physiology
Growth Substances / chemistry*,  physiology*,  secretion
Intercellular Signaling Peptides and Proteins*
Molecular Sequence Data
Pancreas / innervation,  metabolism*
Grant Support
Reg. No./Substance:
0/Growth Substances; 0/Intercellular Signaling Peptides and Proteins

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