| Discovery of NO in the penis. | |
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MedLine Citation:
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PMID: 18385679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 1989, the recognition by our group at UCLA that nitric oxide was indeed the chemical mediator of penile erection turned out to have major influences on our society and on some of those who participated in this research. Not only did it ultimately lead to the development of drugs like sildenafil, vardenafil and tadalafil, it launched new businesses, it gave insight into the way the vascular system functioned, it changed the way many physicians, particularly urologists, practiced sexual medicine and by bringing the topic of erectile dysfunction out of the closet, talk of sexual issues became mainstream. For one of us, a Nobel Prize lay in the future. This review, which comes one decade following the introduction of Viagra into the marketplace, chronicles the actual events involved in the discovery. |
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Authors:
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J Rajfer |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-04-03 |
Journal Detail:
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Title: International journal of impotence research Volume: 20 ISSN: 1476-5489 ISO Abbreviation: Int. J. Impot. Res. Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-09-12 Completed Date: 2009-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007383 Medline TA: Int J Impot Res Country: England |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Affiliation:
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Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90509, USA. jrajfer@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Humans Male Membrane Proteins / metabolism Nitric Oxide / metabolism* Nucleotides, Cyclic / pharmacology Penis / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Nucleotides, Cyclic; 10102-43-9/Nitric Oxide; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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