| Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications. | |
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MedLine Citation:
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PMID: 22168898 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The inhibition of soluble epoxide hydrolase (sEH) by small molecules has been shown to increase the levels of fatty acid epoxides such as epoxyeicosatrienoic acids (EETs), and decrease the levels of the corresponding fatty acid diols including dihydroxyeicosatrienoic acids (DHETs). Due to numerous beneficial effects of EETs, the elevation of their levels, as a result of sEH inhibition, may eventually lead to new therapeutic approaches for multiple diseases. Specifically, it has been shown, largely in rodent models, that sEH inhibitors can be used to treat heart failure, hypertension, diabetes, stroke, dyslipidemia, inflammatory and neuropathic pain, immunological disorders, eye diseases, neurological diseases, and other indications. Medicinal chemistry strategies, key biological data of benchmark compounds, and possible paths for sEH inhibitors to reach the clinic will be reviewed. |
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Authors:
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Hong C Shen; Bruce D Hammock |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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