| Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity. | |
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MedLine Citation:
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PMID: 22244938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorable pharmacokinetic parameters. Based on these attributes, GS-9256 was advanced to human clinical trial as a treatment for chronic infection with genotype 1 HCV. |
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Authors:
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X Christopher Sheng; Anthony Casarez; Ruby Cai; Michael O Clarke; Xiaowu Chen; Aesop Cho; William E Delaney; Edward Doerffler; Mingzhe Ji; Michael Mertzman; Rowchanak Pakdaman; Hyung-Jung Pyun; Tanisha Rowe; Qiaoyin Wu; Jie Xu; Choung U Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Gilead Sciences, Inc., 333 Lakeside Dr, Foster City, CA 94404, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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