| Discovery of FR115092: a novel antinephritic agent. | |
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MedLine Citation:
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PMID: 9871632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of dapsone-related 4-aminopheynl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone. |
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Authors:
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T Ogino; K Tsuji; T Tojo; N Igari; N Seki; Y Sudo; T Manda; F Nishigaki; M Matsuo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 8 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1999-01-26 Completed Date: 1999-01-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Affiliation:
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Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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chemically induced Animals Disease Models, Animal Male Mice Nephritis / drug therapy* Pyridines / chemistry, therapeutic use*, toxicity Thiazoles / chemistry, therapeutic use*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/5-(2-pyridylsulfonyl)-2-thiazolamine; 0/Pyridines; 0/Thiazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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