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Discovering pluripotency: 30 years of mouse embryonic stem cells.
MedLine Citation:
PMID:  21941277     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.
Authors:
Martin Evans
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Publication Detail:
Type:  Journal Article     Date:  2011-09-23
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  12     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Affiliation:
Cardiff University, Museum Avenue, Cardiff, CF10 3AT, Wales, CF10 3XQ, UK. evansmj@cf.ac.uk.
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