Document Detail


Discordant segregation of Na+,K(+)-adenosine triphosphatase alleles and essential hypertension.
MedLine Citation:
PMID:  1357027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine whether the alpha 2 and or beta 1 isoforms of the Na+,K(+)-adenosine triphosphatase (Na+,K(+)-ATPase) are involved in the pathogenesis of essential hypertension. DESIGN: Segregation analysis of polymorphic DNA markers was used to test the involvement of Na+,K(+)-ATPase in essential hypertension. PARTICIPANTS: Children with persistent hypertension having one parent with essential hypertension were included in the study. Criteria for persistent hypertension were blood pressure readings with systolic and/or diastolic levels exceeding the 95th percentile based upon age and sex. The diagnosis of hypertension for adults, including parents and older siblings, was confirmed using criteria recommended in the 1988 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. RESULTS: In three essential hypertensive families consisting of 18 members including 11 hypertensives, several obligate recombinants between the Na+,K(+)-ATPase alpha 2 isoform marker and the hypertension phenotype were observed. Similarly, in one hypertension family consisting of four members, obligate recombinants between the beta 1 isoform marker and the disease were observed. CONCLUSIONS: The discordant segregation of the alpha 2 and beta 1 isoform markers and essential hypertension suggests that neither the Na+,K(+)-ATPase alpha 2 nor beta 1 isoform genes play a primary role in the pathogenesis of hypertension in the families studied.
Authors:
M M Shull; D Hassenbein; J Loggie; S Daniels; A King; T Burton; J B Lingrel
Related Documents :
6413217 - Abnormal na+,k+ cotransport function in a group of patients with essential hypertension.
7236847 - A case of juvenile essential hypertension: implications of erythrocyte net na+, k+ flux...
1629887 - Comparison of office and serial automatic blood pressure readings in renovascular and e...
18384897 - Microalbuminuria and global myocardial function in patients with essential hypertension...
6591207 - Adenosine strongly potentiates pressor responses to nicotine in rats.
11893567 - Mechanical alternans and restitution in failing shhf rat left ventricles.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  10     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1005-10     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Child
DNA / analysis*
Family
Genetic Complementation Test
Humans
Hypertension / genetics*
Isoenzymes / genetics*
Linkage (Genetics)
Nucleic Acid Hybridization
Pedigree
Polymorphism, Restriction Fragment Length
Sodium-Potassium-Exchanging ATPase / genetics*
Grant Support
ID/Acronym/Agency:
P01-HL-41496/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 9007-49-2/DNA; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exp...
Next Document:  The frequency of alpha 2-adrenoceptor restriction fragment length polymorphisms in normotensive and ...