Document Detail

Discordant response of glutathione and thioredoxin systems in human hypertension?
MedLine Citation:
PMID:  17280491     Owner:  NLM     Status:  MEDLINE    
Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans with essential hypertension, with or without treatment, and controls were examined (35 hypertensive and 30 normotensive). We noted a discordant response of the glutathione and thioredoxin systems in essential hypertension and to antihypertensive treatment. Further studies examining the significance of these thiols in hypertension outcomes are warranted.
Maria L Mansego; Sebastian Blesa; Veronica Gonzalez-Albert; Maria C Tormos; Guillermo Saez; Josep Redon; Felipe J Chaves
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  9     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Laboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain.
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MeSH Terms
Antioxidants / metabolism
Gene Expression
Glutathione / blood,  genetics*,  metabolism
Hypertension / blood,  genetics*,  metabolism
Middle Aged
Oxidative Stress
RNA, Messenger / genetics,  metabolism
Thioredoxins / blood,  genetics*,  metabolism
Reg. No./Substance:
0/Antioxidants; 0/RNA, Messenger; 52500-60-4/Thioredoxins; 70-18-8/Glutathione

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