| Discordant pregnancy tests in detection of alpha-subunit--producing tumors. | |
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MedLine Citation:
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PMID: 6185896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ectopic production of isolated alpha-subunit of glycoprotein hormones was detected in a 32-year-old Japanese woman with metastatic lung tumor by a discordance in the immunologic pregnancy tests for native human chorionic gonadotropin (hCG) assays. Quantitative discrepancy of titrations among different types of pregnancy tests, ie, competitive (hemagglutination or latexagglutination inhibition) and noncompetitive (hemagglutination or latexagglutination) reactions, was also confirmed experimentally using a highly purified ectopic alpha-subunit from the patient's urine. Thus the discrepancy between the 2 types of assay systems was due, at least partly, to a cross-reaction of high concentrations (20,000 ng/ml) of ectopically secreted free alpha-subunit of glycoprotein hormones. |
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Authors:
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N Morimoto; M Ozawa; R Nishimura; T Hamamoto; S Tojo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 61 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 379-83 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / metabolism Chorionic Gonadotropin / urine Cross Reactions False Positive Reactions Female Glycoprotein Hormones, alpha Subunit Glycoproteins / analysis, secretion* Hemagglutination Inhibition Tests Hormones, Ectopic / secretion* Humans Latex Fixation Tests Lung Neoplasms / secondary*, secretion Peptide Fragments / analysis, secretion* Pregnancy Tests* Pregnancy Tests, Immunologic |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Glycoprotein Hormones, alpha Subunit; 0/Glycoproteins; 0/Hormones, Ectopic; 0/Peptide Fragments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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