| Discordant blood chimerism in dizygotic monochorionic laser-treated twin-twin transfusion syndrome. | |
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MedLine Citation:
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PMID: 20664426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Twin-twin transfusion syndrome occurs in 10% of monozygotic monochorionic twin gestations and results from an unbalanced exchange of blood from the donor to the recipient fetus through placental anastomoses. CASE: We present a case of twin-twin transfusion syndrome with differing fetal sex treated with in utero laser surgery. Genetic analyses showed 46,XX/46,XY hematologic chimerism in both twins at birth and at 6 months, with the recipient twin being significantly more chimeric than the donor. Placental pathologic examination confirmed monochorionicity and laser ablation of all anastomoses. CONCLUSION: Despite in utero separation of the fetal circulations remote from delivery, hematologic chimerism persisted after birth. We speculate that the greater degree of blood chimerism in the recipient compared with the donor was related to the pathophysiology of twin-twin transfusion syndrome before laser surgery. |
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Authors:
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Samer A Assaf; Linda M Randolph; Kurt Benirschke; Samuel Wu; Ramin Samadi; Ramen H Chmait |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 116 Suppl 2 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-24 Revised Date: 2010-11-08 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 483-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Group Antigens* Chimerism* Female Fetofetal Transfusion / physiopathology, surgery* Humans Laser Therapy Pregnancy Twins |
| Chemical | |
Reg. No./Substance:
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0/Blood Group Antigens |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 2010 Aug;116 Suppl 2:475-6
[PMID:
20664423
]
Obstet Gynecol. 2010 Nov;116(5):1219 [PMID: 20966719 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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