| Discordance in nuchal translucency measurements in monochorionic diamniotic twins as predictor of twin-to-twin transfusion syndrome. | |
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MedLine Citation:
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PMID: 19943724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Discordance in nuchal translucency measurements in monochorionic diamniotic twin pregnancies was assessed as predictor of Twin-to-Twin Transfusion Syndrome. STUDY DESIGN: A total of 61 monochorionic diamniotic twins were enrolled. Nuchal translucency (NT) and crown-rump-length (CRL) discordance was calculated as the percentage of delta NT and CRL (absolute difference NT/CRL fetus 1 and fetus 2) of the largest measurement, and correlated with subsequent development of Twin-to-Twin Transfusion Syndrome. RESULTS: Twin-to-Twin Transfusion Syndrome developed in 14/61 (23%) of cases. A NT discordance of 20% or more best predicted Twin-to-Twin Transfusion Syndrome development, with a sensitivity of 64% and a specificity of 78%. We found a positive predictive value of 50% and negative predicted value of 86% for Twin-to-Twin Transfusion Syndrome development if NT discordance was 20% or more. CONCLUSION: NT discordance of more than 20% in monochorionic diamniotic twins is associated with an increased risk for subsequent development of Twin-to-Twin Transfusion Syndrome, and with earlier presentation of symptoms. |
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Authors:
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Ingeborg H Linskens; Yolanda M de Mooij; Jos W Twisk; Willem J Kist; Dick Oepkes; John M van Vugt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 12 ISSN: 1832-4274 ISO Abbreviation: Twin Res Hum Genet Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
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Languages: eng Pagination: 605-10 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands. I.Linskens@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetofetal Transfusion / diagnosis, ultrasonography* Humans Male Nuchal Translucency Measurement* Predictive Value of Tests Pregnancy Twins* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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