| Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 16948806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The proportion of proton pump inhibitor users on long-term therapy who can discontinue proton pump inhibitor (PPI) medication without developing symptoms is unknown. AIM: To determine the proportion of patients on long-term PPI therapy who are able to discontinue PPIs without developing symptoms. METHODS: Patients on long-term PPIs, without a history of peptic ulcer or esophagitis underwent upper endoscopy. Patients were randomized double-blindly to taper down or continue a constant dosage of omeprazole for three weeks. Thereafter, all patients discontinued PPIs. RESULTS: Of the 97 patients enrolled, had used PPIs for 48 months, 78% had GERD. A total of 27% did not use PPIs during the year after discontinuation, 31% of the patients randomized to tapering discontinued PPIs and 22% of those who did not could discontinue therapy (NS). Gastro-oesophageal reflux disease (GERD) patients were more prone to continue PPIs than non-GERD patients. Only 16 (21%) of GERD patients were off PPIs vs. 48% of patients without GERD (p < 0.05). Serum gastrin was higher at baseline in GERD patients who resumed PPIs versus non-resumers (p < 0.05). GERD and serum gastrin were independent predictors of PPI requirement. CONCLUSIONS: Discontinuation of PPI was successful in 27% of long-term PPI users. GERD patients had more difficulty discontinuing PPIs than non-GERD patients. |
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Authors:
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E Björnsson; H Abrahamsson; M Simrén; N Mattsson; C Jensen; P Agerforz; A Kilander |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 24 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2007-03-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 945-54 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden. einar.bjornsson@medic.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Double-Blind Method Drug Administration Schedule Dyspepsia / blood, drug therapy Enzyme Inhibitors / administration & dosage* Female Gastrins / blood Gastroesophageal Reflux / blood, drug therapy* Humans Long-Term Care Male Middle Aged Omeprazole / administration & dosage Proton Pumps / antagonists & inhibitors* Quality of Life Treatment Outcome Withholding Treatment |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Gastrins; 0/Proton Pumps; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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