| Discontinuation of proton pump inhibitors during assessment of chromogranin A levels in patients with neuroendocrine tumours. | |
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MedLine Citation:
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PMID: 21989216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this prospective study was to examine whether discontinuation of proton pump inhibitors (PPIs) or replacement by H(2)-receptor antagonists (H2RA) resulted in a decrease of chromogranin A (CgA) levels in 196 patients with well-differentiated neuroendocrine tumours (NETs). METHODS: Patients with an unexpectedly high CgA level not connected with NET disease discontinued PPIs, or used H2RA instead; 2 weeks later CgA level was measured again.Results:In all, 19 out of 196 (10%) patients showed unexpected elevated CgA levels, they all used PPI. In 11 out of 19 patients with no evidence of the disease, median CgA decreased from 390 μg l(-1) during PPI treatment to 56 μg l(-1) after discontinuation (P=0.003). In 8 out of 19 patients with stable disease, median CgA decreased from 618 to 318 μg l(-1) (P=0.012). In 12 out of 19 patients who ceased all acid inhibition, CgA levels decreased by 82%, while in the seven patients who replaced PPI by H2RA, CgA decreased by 77% (P=0.967). CONCLUSION: Proton pump inhibitor use causes falsely elevated CgA levels in patients with NET. We recommend to stop, or replace PPI by H2RA, to obtain a reliable CgA value. |
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Authors:
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C M Korse; M Muller; B G Taal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of cancer Volume: 105 ISSN: 1532-1827 ISO Abbreviation: Br. J. Cancer Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-12 Completed Date: 2011-11-21 Revised Date: 2011-12-02 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 1173-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, PO Box 90203, 1006 BE Amsterdam, The Netherlands. t.korse@nki.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Chromogranin A / metabolism* Female Humans Male Middle Aged Neuroendocrine Tumors / metabolism* Proton Pump Inhibitors / administration & dosage* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A; 0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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