Document Detail

Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke.
MedLine Citation:
PMID:  9403661     Owner:  NLM     Status:  MEDLINE    
Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up.
S Rana; P E Houston; N Surana; E I Shalaby-Rana; O L Castro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  131     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  757-60     Citation Subset:  AIM; IM    
Department of Medicine, Harvard University College of Medicine, Washington, D.C., USA.
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MeSH Terms
Anemia, Sickle Cell / blood,  complications*,  therapy*
Blood Transfusion*
Cerebral Infarction / blood,  etiology*
Follow-Up Studies
Hemoglobin, Sickle / metabolism
Time Factors
Reg. No./Substance:
0/Hemoglobin, Sickle

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