Document Detail

Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding.
MedLine Citation:
PMID:  20807106     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study compared mothers' report of symptoms of discontinuation syndrome in infants exposed to antidepressants both in utero and during lactation to infants who were exposed only during lactation.
STUDY DESIGN: This is a convenience sample of 930 women breastfeeding women who answered an online questionnaire about antidepressant use while pregnant and breastfeeding. All 930 women had taken antidepressants while breastfeeding, and 527 had also taken antidepressants during pregnancy. There were no participants in the present study who had taken antidepressants only during pregnancy. The questionnaire was posted on the first author's Medications and Breastfeeding Forum. There was no advertising of this study, nor were efforts made to recruit women into this study beyond posting a notice on the website. The questionnaire included a list of symptoms that mothers may have observed in their infants during the newborn period, as well as demographic questions, and questions about antidepressant use during pregnancy and lactation.
RESULTS: The majority of women reported that their infants never experienced the symptoms of discontinuation syndrome. Twenty-five percent reported infant irritability. A smaller percentage reported inconsolable crying (17%), low body temperature (14%), and significant problems with eating and sleeping (15%). Logistic regression revealed that mothers who took antidepressants while pregnant and then during breastfeeding were two to eight times more likely to report symptoms of discontinuation syndrome than women who took them only while breastfeeding. Discontinuation symptoms were more likely to occur in infants whose mothers took medications with shorter half-lives.
CONCLUSIONS: Discontinuation syndrome does occur in a small percentage of infants exposed to antidepressants in utero. Mothers reported a higher frequency of discontinuation syndrome after in utero exposure followed by breastfeeding than when infants were exposed to antidepressants only during lactation.
Thomas W Hale; Kathleen Kendall-Tackett; Zhen Cong; Richard Votta; Fred McCurdy
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Publication Detail:
Type:  Journal Article     Date:  2010-08-31
Journal Detail:
Title:  Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine     Volume:  5     ISSN:  1556-8342     ISO Abbreviation:  Breastfeed Med     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-20     Revised Date:  2011-03-25    
Medline Journal Info:
Nlm Unique ID:  101260777     Medline TA:  Breastfeed Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
Department of Pediatrics, Texas Tech University School of Medicine, Amarillo, 79106, USA.
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MeSH Terms
Antidepressive Agents / adverse effects*
Breast Feeding
Depressive Disorder / drug therapy*
Infant, Newborn
Milk, Human / chemistry*
Neonatal Abstinence Syndrome / epidemiology*
Pregnancy Complications / drug therapy*
Pregnancy Outcome
Young Adult
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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