| Discoid lupus erythematosus of the periorbita: clinical dilemmas, diagnostic delays. | |
| | |
MedLine Citation:
|
PMID: 22241018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Untreated periocular discoid lupus erythematosus (DLE), though very rare, may lead to significant morbidity with lid deformities, trichiasis, and symblepharon formation. We present the largest reported cohort of patients with biopsy-proven DLE solely affecting the periorbital region. METHODS: Observational case series of patients managed over a 7-year period (2004-10). RESULTS: Seven patients (one male) presented to the Adnexal Service at Moorfields Eye Hospital at a median age of 47 years (range 23-71 years); median interval from symptom onset to biopsy-proven diagnosis was 38 months (range 6-86 months). Changes in peripheral skin were present in 1 patient (occurring after the initial eyelid presentation) and the presenting periocular features were dissimilar across the group, these included: chronic blepharo-conjunctivitis, madarosis, atypical chalazia, depigmentation of the eyelid margin, or marked, persistent periocular oedema with dacryoadenitis.Two cases settled spontaneously, but five required systemic hydroxychloroquine or intralesional corticosteroid injections. CONCLUSION: Periorbital DLE is rare and very varied in its presentation, the protean manifestations often resulting in significant diagnostic delay. All patients with unusual periocular skin disease and those with a refractory inflammatory dermopathy, should undergo biopsy of involved tissue(s), thus leading to earlier diagnosis and prevention of permanent cicatricial periocular changes. |
| | |
Authors:
|
T Gupta; M Beaconsfield; G E Rose; D H Verity |
Related Documents
:
|
21552298 - The outcome of allo-hsct for 92 patients with myelofibrosis in the nordic countries. 21181928 - Soluble cd30: a serum marker for epstein-barr virus-associated lymphoproliferative dise... 17564728 - Long-term follow-up of argentinean patients with hemolytic uremic syndrome who had not ... 21526998 - The reliability of an arabic version of the self-administered standardised chronic resp... 12605978 - Prospective study of neuropsychologic testing and quality-of-life assessment of adults ... 18415758 - Colonic lavage with two polyethylene glycol solutions prior to colonoscopy makes no dif... |
Publication Detail:
|
Type: Journal Article Date: 2012-01-13 |
Journal Detail:
|
Title: Eye (London, England) Volume: 26 ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-04-12 Completed Date: 2012-06-05 Revised Date: 2013-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 609-12 Citation Subset: IM |
Affiliation:
|
Adnexal Department, Moorfields Eye Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Adult Aged Cohort Studies Enzyme Inhibitors / therapeutic use Female Humans Hydroxychloroquine / therapeutic use Longitudinal Studies Lupus Erythematosus, Discoid / diagnosis, drug therapy, pathology* Male Middle Aged Orbital Diseases / diagnosis, drug therapy, pathology* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Enzyme Inhibitors; 118-42-3/Hydroxychloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Visual outcome in Japanese patients with Acanthamoeba keratitis.
Next Document: Assessing Graves' ophthalmopathy-specific quality of life in Korean patients.