Document Detail


Discharge patterns in the lateral superior olive of decerebrate cats.
MedLine Citation:
PMID:  22745462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anatomical and pharmacological studies have shown that the lateral superior olive (LSO) receives inputs from a number of sources and that LSO cells can alter the balance of their own excitatory and inhibitory drive. It is thus likely that the ongoing sound-evoked responses of LSO cells reflect a complex interplay of excitatory and inhibitory events, which may be affected by anesthesia. The goal of this study was to characterize the temporal discharge patterns of single units in the LSO of unanesthetized, decerebrate cats in response to long-duration ipsilateral best-frequency tone bursts. A decision tree is presented to partition LSO units on the basis of poststimulus time histogram shape, adaptation of instantaneous firing rate as a function of time, and sustained discharge rate. The results suggest that LSO discharge patterns form a continuum with four archetypes: sustained choppers that show two or more peaks of activity at stimulus onset and little adaptation of rate throughout the response, transient choppers that undergo a decrease in rate that eventually stabilizes with time, primary-like units that display an initial peak of activity followed by a monotonic decline in rate to a steady-state value, and onset-sustained units that exhibit an initial peak of activity at stimulus onset followed by a low sustained activity. Compared with the chopper units, the nonchopper units tend to show longer first-spike latencies, lower peak firing rates, and more irregular sustained discharge patterns. Modeling studies show that the full range of LSO response types can be obtained from an underlying sustained chopper by varying the strength and latency of a sound-driven ipsilateral inhibition relative to that of excitation. Together, these results suggest that inhibition plays a major role in shaping the temporal discharge patterns of units in unanesthetized preparations.
Authors:
Nathaniel T Greene; Kevin A Davis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-27
Journal Detail:
Title:  Journal of neurophysiology     Volume:  108     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-06-14     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1942-53     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Animals
Auditory Pathways / physiology*
Brain Stem / physiology*
Cats
Decerebrate State / physiopathology*
Models, Neurological
Grant Support
ID/Acronym/Agency:
P30 DC05409/DC/NIDCD NIH HHS; R01 DC 05161/DC/NIDCD NIH HHS; T32 DC009974/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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