Document Detail


Disasters and the heart: a review of the effects of earthquake-induced stress on cardiovascular disease.
MedLine Citation:
PMID:  12887126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is growing evidence that stress contributes to cardiovascular disease. Chronic stress contributes to the atherosclerotic process through increased allostatic load, which is mediated by the neuroendocrine and immune systems (sympathetic nervous system and hypothalamus-pituitary adrenal axis) and related chronic risk factors (insulin resistance syndrome, hypertension, diabetes, and hyperlipidemia). In addition, acute stress can trigger cardiovascular events predominantly through sympathetic nervous activation and potentiation of acute risk factors (blood pressure increase, endothelial cell dysfunction, increased blood viscosity, and platelet and hemostatic activation). Earthquakes provide a good example of naturally occurring acute and chronic stress, and in this review we focus mainly on the effects of the Hanshin-Awaji earthquake on the cardiovascular system. The Hanshin-Awaji earthquake resulted in a 3-fold increase of myocardial infarctions in people living close to the epicenter, particularly in women, with most of the increase occurring in nighttime-onset events. There was also a near doubling in the frequency of strokes. These effects may be mediated by changes in hemostatic factors, as demonstrated by an increase of D-dimer, von Willebrand factor, and tissue-type plasminogen activator (tPA) antigen. Blood pressure also increased after the earthquake, and was prolonged for several weeks in patients with microalbuminuria.
Authors:
Kazuomi Kario; Bruce S McEwen; Thomas G Pickering
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  26     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  355-67     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Jichi Medical School, Tochigi, Japan. kkario@jichi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / epidemiology*,  physiopathology*
Disasters*
Humans
Risk Factors
Stress, Physiological / epidemiology*,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-47540/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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