| Disappearance of cerebrospinal fluid oligoclonal bands after natalizumab treatment of multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 22041091 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Intrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known. |
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Authors:
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Felipe von Glehn; Alessandro S Farias; Augusto C Penalva de Oliveira; Alfredo Damasceno; Ana Leda F Longhini; Elaine C Oliveira; Benito P Damasceno; Leonilda Mb Santos; Carlos Otávio Brandão |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-31 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: - ISSN: 1477-0970 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neuroimmunology Unit, Department of Genetics/Dept of Neurology, Evolution and Bioagents, University of Campinas - UNICAMP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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