Document Detail

Disappearance of Ph1 chromosome with intensive chemotherapy and detection of minimal residual disease by polymerase chain reaction in a patient with blast crisis of chronic myelogenous leukemia.
MedLine Citation:
PMID:  8364186     Owner:  NLM     Status:  MEDLINE    
We diagnosed a patient with chronic myelogenous leukemia (CML) in chronic phase (CP) on the basis of clinical findings, Ph1 chromosome detected by cytogenetic analysis, and bcr-abl fusion mRNA detected by reverse transcriptase-dependent polymerase chain reaction (RT-PCR). One month after diagnosis, the patient developed extramedullary blast crisis in the lymph nodes, and then medullary blast crisis in the bone marrow, in which different surface markers were shown. Combination chemotherapy with BH-AC, VP16, and mitoxantrone was administered; this resulted in rapid disappearance of the lymphadenopathy, restoration of normal hematopoiesis, and no Ph1 chromosome being detected by cytogenetic analysis. RT-PCR performed to detect the residual Ph1 clone revealed that although the Ph1 clone was preferentially suppressed, it was still residual. The intensive chemotherapy regimen preferentially suppressed the Ph1-positive clone and led to both clinical and cytogenetic remission in this patient with BC of CML; we suggest that RT-PCR is a sensitive and useful method for detecting minimal residual disease during the clinical course of this disease.
H Honda; K Miyagawa; M Endo; F Takaku; Y Yazaki; H Hirai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  57     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-05     Completed Date:  1993-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Blast Crisis / drug therapy*,  genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*,  genetics
Leukemia, Myeloid, Chronic-Phase / drug therapy*,  genetics
Philadelphia Chromosome*
Polymerase Chain Reaction

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