Document Detail

Disability and functional profiles of patients with myasthenia gravis measured with ICF classification.
MedLine Citation:
PMID:  19458525     Owner:  NLM     Status:  MEDLINE    
The objective of this study is to describe functional profiles of patients with myasthenia gravis (MG), and the relationships among symptoms, activities and environmental factors (EF), by using WHO's International Classification of Functioning Disability and Health (ICF). Patients were consecutively enrolled at the Besta Institute of Milan, Italy. The ICF checklist was administered and two count-based indices were developed: 'extension', containing ICF categories rated with qualifiers 1-4, and 'severity', containing ICF categories rated with qualifiers 3-4. Spearman's correlation was performed to identify the relationships among symptoms, activities and EF, and linear regressions to identify the best predictors of performance indices in the activities and participation (A and P) domains. One hundred and one patients joined this study. Different values are reported in capacity and performance, the latter being 17.1% less limited in 'extension' and 13% in 'severity' index. Higher correlation indices are observed between A and P and body functions (BFs), than between A and P and EF. Problems in A and P are better explained by BF impairments than by facilitators within EF. In conclusion, EF plays a relevant role in improving MG patients' functioning. Nevertheless, difficulties in A and P, such as lifting objects or doing housework, are explained more by impairments in BF (e.g. in muscle endurance) than by the effect of EF (e.g. drugs and the support of family members). Methodologies and tools are needed to couple symptoms assessment with an evaluation of difficulties in executing activities and the environment's role, to plan appropriate interventions to meet MG patients' needs, especially in the labour sector, as 20% of patients gave up working before the retirement age.
Matilde Leonardi; Alberto Raggi; Carlo Antozzi; Paolo Confalonieri; Lorenzo Maggi; Ferdinando Cornelio; Renato Mantegazza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of rehabilitation research. Internationale Zeitschrift für Rehabilitationsforschung. Revue internationale de recherches de réadaptation     Volume:  32     ISSN:  1473-5660     ISO Abbreviation:  Int J Rehabil Res     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805421     Medline TA:  Int J Rehabil Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Neurological Institute C. Besta, IRCCS Foundation - Neurology, Public Health and Disability Unit, Scientific Directorate, Milan, Italy.
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MeSH Terms
Disabled Persons / rehabilitation*
Linear Models
Mentha spicata
Middle Aged
Myasthenia Gravis / classification,  rehabilitation*
Severity of Illness Index
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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