| Directional selectivity is formed at multiple levels by laterally offset inhibition in the rabbit retina. | |
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MedLine Citation:
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PMID: 15820698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The excitatory and inhibitory inputs to directionally selective (DS) ganglion cells are themselves directionally selective. Directionality is achieved because excitation is reduced during null-direction movement along a GABAergic pathway. Inhibition is reduced during preferred-direction movement along a pathway that includes cholinergic synapses. Both excitation and inhibition are made directional by laterally offset inhibitory signals similar to the spatial offset of the direct inhibitory input to the DS cell dendrites. Thus, spatially offset lateral inhibition generates directionality at three different levels in the DS circuitry. We also found that for stimuli falling within the dendritic field, cholinergic input is delivered to the OFF but not the ON dendrites. Cholinergic pathways from outside the dendritic field reach both ON and OFF dendrites, but both of these pathways are normally inactivated by GABAergic synapses. |
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Authors:
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Shelley I Fried; Thomas A Münch; Frank S Werblin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuron Volume: 46 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-11 Completed Date: 2005-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 117-27 Citation Subset: IM |
Affiliation:
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Vision Science, University of California at Berkeley, 145 LSA, Berkeley, California 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Amacrine Cells / physiology Animals Evoked Potentials, Visual / physiology Glutamic Acid / metabolism Neural Inhibition / physiology* Organ Culture Techniques Rabbits Retina / physiology* Retinal Ganglion Cells / physiology* Visual Perception / physiology* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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