Document Detail

Directional porosity of porcine small-intestinal submucosa.
MedLine Citation:
PMID:  8245038     Owner:  NLM     Status:  MEDLINE    
Small-intestinal submucosa (SIS) has been shown to be a promising biomaterial for vascular graft applications. This study examines the directionality property of SIS porosity using 35 SIS specimens from 13 pigs. In addition, the effects of the weight of the donor pig, pre-conditioning of 13 additional SIS specimens, and the duration of the test of five additional SIS specimens on such porosity are reported. The porosity from serosal to mucosal direction was found to be four times greater than the porosity in the opposite direction. The weight of the donor pig was not found to be an important factor in SIS porosity. Preconditioning served to increase the average serosal porosity index at 120 mm Hg static water pressure from 2.99 to 8.33 mL/(min cm2). The porosity in the mucosal direction was not affected by preconditioning. Porosity in both directions decreased with increasing test duration. The directionality property of SIS porosity may be an important factor in its success as a vascular graft. The term 'porosity' is used throughout this article, but current standards also refer to the term 'permeability' to describe the passage of liquid through a vascular graft.
B K Ferrand; K Kokini; S F Badylak; L A Geddes; M C Hiles; R J Morff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  27     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-23     Completed Date:  1993-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1235-41     Citation Subset:  IM    
School of Mechanical Engineering, Purdue University, W. Lafayette, IN 47907.
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MeSH Terms
Biocompatible Materials*
Blood Vessel Prosthesis*
Body Weight
Intestinal Mucosa / physiology
Intestine, Small* / physiology
Jejunum* / physiology
Muscle, Smooth / physiology
Regression Analysis
Reg. No./Substance:
0/Biocompatible Materials

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