| Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves. | |
| | |
MedLine Citation:
|
PMID: 18498732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Direction selectivity in the retina requires the asymmetric wiring of inhibitory inputs onto four subtypes of On-Off direction-selective ganglion cells (DSGCs), each preferring motion in one of four cardinal directions. The primary model for the development of direction selectivity is that patterned activity plays an instructive role. Here, we use a unique, large-scale multielectrode array to demonstrate that DSGCs are present at eye opening, in mice that have been reared in darkness and in mice that lack cholinergic retinal waves. These data suggest that direction selectivity in the retina is established largely independent of patterned activity and is therefore likely to emerge as a result of complex molecular interactions. |
| | |
Authors:
|
Justin Elstrott; Anastasia Anishchenko; Martin Greschner; Alexander Sher; Alan M Litke; E J Chichilnisky; Marla B Feller |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Neuron Volume: 58 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-23 Completed Date: 2008-06-25 Revised Date: 2012-05-15 |
Medline Journal Info:
|
Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
|
Languages: eng Pagination: 499-506 Citation Subset: IM |
Affiliation:
|
Neuroscience Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA. jelstrott@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
metabolism* Action Potentials / physiology Adaptation, Ocular / physiology Age Factors Animals Animals, Newborn Mice Mice, Inbred C57BL Mice, Knockout Motion Perception / physiology* Orientation / physiology* Photic Stimulation / methods Receptors, Nicotinic / deficiency Retina / cytology* Retinal Ganglion Cells / physiology* Vision, Ocular / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
EY018003/EY/NEI NIH HHS; R01 EY013528-02/EY/NEI NIH HHS; R01 EY019498/EY/NEI NIH HHS; R01 EY019498-01/EY/NEI NIH HHS; R01EY13528/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Nicotinic; 0/nicotinic receptor beta2; 51-84-3/Acetylcholine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glutamate receptor dynamics in dendritic microdomains.
Next Document: Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP sign...