| Direction-selective ganglion cells show symmetric participation in retinal waves during development. | |
| | |
MedLine Citation:
|
PMID: 20720127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Direction-selective ganglion cells (DSGCs) fire robustly for stimuli moving along one direction of motion and are strongly inhibited by stimuli moving in the opposite, or null, direction. In contrast to direction-selective neurons in primary visual cortex, a role for neural activity in the development of direction-selective retinal circuits has not been established. Direction-selective responses are detected at eye opening, before which spontaneous correlated activity known as retinal waves provide directional input to ganglion cells. Indeed, we observed a significant bias in wave propagation along the nasal over temporal direction. Using simultaneous calcium imaging and cell-attached recordings from three genetically labeled DSGC types in mice, we observed that all three DSGC types fire action potentials during retinal waves. However, we found that the direction of wave propagation did not influence DSGC spiking. These results indicate that the mechanisms guiding the formation of the asymmetric inhibition underlying direction selectivity in the retina are not dependent upon the directional properties of retinal waves. |
| | |
Authors:
|
Justin Elstrott; Marla B Feller |
Related Documents
:
|
2911737 - Mental rotation of the neuronal population vector. 2017027 - Size invariance in curve tracing. 10630477 - A biologically plausible acoustic motion detection neural network. 16153677 - The predictive power of trajectory motion. 7451377 - Processing of noise by single units of the inferior colliculus of the bar rhinolophus f... 6791787 - Bone photovoltaic cell in hall geometry. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-19 Completed Date: 2010-09-03 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 11197-201 Citation Subset: IM |
Affiliation:
|
Department of Molecular and Cell Biology and Helen Wills Neurosciences Institute, University of California, Berkeley, Berkeley, California 94720, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
physiology Animals Animals, Newborn Calcium / metabolism Female Male Membrane Potentials / physiology Mice Mice, Inbred C57BL Mice, Transgenic Neural Inhibition / physiology Retina / growth & development*, physiology* Retinal Ganglion Cells / physiology* Vision, Ocular / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
ARRAEYE019498//PHS HHS; R01 EY013528-01A1/EY/NEI NIH HHS; R01 EY019498-02/EY/NEI NIH HHS; R01EY013528/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus...
Next Document: Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in...