Document Detail


Directed assembly of cell-laden hydrogels for engineering functional tissues.
MedLine Citation:
PMID:  21220962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue engineering aims to develop functionalized tissues for organ replacement or restoration. Biodegradable scaffolds have been used in tissue engineering to support cell growth and maintain mechanical and biological properties of tissue constructs. Ideally cells on these scaffolds adhere, proliferate, and deposit matrix at a rate that is consistent with scaffold degradation. However, the cellular rearrangement within these scaffolds often does not recapitulate the architecture of the native tissues. Directed assembly of tissue-like structures is an attractive alternative to scaffold-based approach for tissue engineering which potentially can build tissue constructs with biomimetic architecture and function. In directed assembly, shape-controlled microstructures are fabricated in which organized structures of different cell types can be used as tissue building blocks. To fabricate tissue building blocks, hydrogels are commonly used as biomaterials for cell encapsulation to mimic the matrix in vivo. The hydrogel-based tissue building blocks can be arranged in pre-defined architectures by various directed tissue assembly techniques. In this paper, recent advances in directed assembly-based tissue engineering are summarized as an emerging alternative to meet challenges associated with scaffold-based tissue engineering and future directions are addressed.
Authors:
Nezamoddin N Kachouie; Yanan Du; Hojae Bae; Masoud Khabiry; Amirhossein F Ahari; Behnam Zamanian; Junji Fukuda; Ali Khademhosseini
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Organogenesis     Volume:  6     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-06-06     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-44     Citation Subset:  IM    
Affiliation:
Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / chemistry*
Emulsions
Humans
Hydrogels / chemical synthesis,  chemistry*
Microfluidics
Tissue Engineering*
Tissue Scaffolds / chemistry*
Grant Support
ID/Acronym/Agency:
DE019024/DE/NIDCR NIH HHS; EB007249/EB/NIBIB NIH HHS; HL092836/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Emulsions; 0/Hydrogels
Comments/Corrections

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