Document Detail

Direct voltammetric specific recognition of dopamine using AlIII-DA complexes at the hanging mercury drop electrode.
MedLine Citation:
PMID:  17998754     Owner:  NLM     Status:  MEDLINE    
In this paper, we firstly report the direct voltammetric recognition and determination of dopamine (DA) by using Al(III)-DA complexes at the hanging mercury drop electrode (HMDE). A new sensitive cathodic peak of Al(III)-DA can be detected at -900 mV (vs. SCE) in 0.1 M NH(4)Cl-NH(3).H(2)O-0.1 M KCl buffer solution at pH 8.5. This unique -900 mV cathodic peak arises from the specific interaction between Al(III) and DA on the HMDE, whereas other substances with similar structures, such as L-dopa, epinephrine (EP), norepinephrine (NE), catechols, caffeic acid (CA), trihydric phenols and tiron, do not yield any new peak on the voltammograms in the potential range from -100 to -1200 mV when Al(III) is added. The distinct voltammetric characteristic of the recognition of DA can effectively inhibit the interferences of both ascorbic acid and uric acid in the DA determination by the direct electrochemistry, which is a major difficulty when a solid electrode is used. The proposed method can be anticipated as an effective means for the recognition of DA in the elucidation of the mechanisms of Parkinson's disease (PD) and Alzheimer's disease (AD) in the presence of Al(III).
Fuping Zhang; Min Zhang; Jiongjia Cheng; Li Yang; Ming Ji; Shuping Bi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry     Volume:  23     ISSN:  0910-6340     ISO Abbreviation:  Anal Sci     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-13     Completed Date:  2008-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511078     Medline TA:  Anal Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1325-9     Citation Subset:  IM    
School of Chemistry & Chemical Engineering, MOE Key Laboratory for Life Science & State Key Laboratory of Coordination Chemistry of China, Nanjing University.
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MeSH Terms
Aluminum Compounds / analysis*,  chemistry*
Dopamine / analysis*,  chemistry*
Mercury / chemistry*
Molecular Structure
Reg. No./Substance:
0/Aluminum Compounds; 7439-97-6/Mercury

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